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1.
Actas Urol Esp ; 31(4): 417-9, 2007 Apr.
Artigo em Espanhol | MEDLINE | ID: mdl-17633930

RESUMO

OBJECTIVE: Paratesticular tumors are very rare and mostly bening. Wa aport a new case of adenomatoid tumor of epididymis METHOD: Male of 40 years old with solid lesion in epidididymis tale treated with mass exéresis RESULTS: Adenoamotid tumor of the epididymis confirmed with hystopathologic technique CONCLUSION: Adenomatoid tumor of epididymis is the most frequent paratesticular tumors and when is suspected, conservative surgery must be performed.


Assuntos
Tumor Adenomatoide , Epididimo , Neoplasias dos Genitais Masculinos , Tumor Adenomatoide/diagnóstico , Tumor Adenomatoide/cirurgia , Adulto , Neoplasias dos Genitais Masculinos/diagnóstico , Neoplasias dos Genitais Masculinos/cirurgia , Humanos , Masculino
2.
Actas urol. esp ; 31(4): 417-419, abr. 2007. ilus
Artigo em Es | IBECS | ID: ibc-054100

RESUMO

Objetivo: Los tumores paratesticulares son poco habituales siendo en la mayoría de los casos benignos. Aportamos un nuevo caso de tumor adenomatoide de epidídimo. Método: Varón de 40 años con masa sólida en cola epidídimo tratada mediante exéresis de la misma Resultados: Tumor adenomatoide confirmado mediante inmunohistoquímica Conclusión: El tumor adenomatoide es el más frecuente de los tumores paratesticulares y su sospecha permite realizar cirugía conservadora


Objective: Paratesticular tumors are very rare and mostly bening. Wa aport a new case of adenomatoid tumor of epididymis Method: Male of 40 years old with solid lesion in epidididymis tale treated with mass exéresis Results. Adenoamotid tumor of the epididymis confirmed with hystopathologic technique Conclusion: Adenomatoid tumor of epididymis is the most frequent paratesticular tumors and when is suspected, conservative surgery must be performed


Assuntos
Masculino , Adulto , Humanos , Epididimo/patologia , Tumor Adenomatoide/patologia , Neoplasias Testiculares/patologia , Imuno-Histoquímica
3.
Actas Urol Esp ; 30(9): 871-8, 2006 Oct.
Artigo em Espanhol | MEDLINE | ID: mdl-17175927

RESUMO

INTRODUCTION: The natural history of the superficial carcinoma of bladder is characterized by his high rate of recurrence and by the aptitude to progress to higher stages. We are going to investigate the capacity of prediction for tumor recurrence of protein p53, antigen Ki-67, E Cadherin and Beta Catenin MATERIAL AND METHOD: 88 T1 tumors with a median of free time of disease of 36 months. 58% of the serie has received prophylactic treatment with BCG 81 mg. weekly for six weeks. Cut-oof level for For P53 and Ki-67 is 10 % of stained cells. For E Cadherin and Beta Catenin we have established two groups: one with the values 0-4 (negative), and other one with the values 5-8 (positive). RESULTS: Recurrence rate 31%, stage progression 3%. Ki-67 expression is correlated with grade (p .002) and lymphatic permeation (p .028). Multiplicity is correlated with lack( of Cadherin and Catenin's expression. Only Ki-67 expression (p .049) and lack of Beta Catenin expression (p .039) reach statistical significance. In multivariant study only lack of Beta Catenin's expression shows independent recurrence value (p .049; O.R: 2,4-6,9) CONCLUSIONS: The most useful prognmostic markers are Ki-67 and Catenina Beta Only Beta Catenin Beta shows independent value for tumour recurrence. Tumors wich lack expression for Catenin B or Cadherin E have lower recurrence free time.


Assuntos
Caderinas/biossíntese , Carcinoma de Células de Transição/metabolismo , Antígeno Ki-67/biossíntese , Proteína Supressora de Tumor p53/biossíntese , Neoplasias da Bexiga Urinária/metabolismo , beta Catenina/biossíntese , Caderinas/análise , Carcinoma de Células de Transição/química , Humanos , Antígeno Ki-67/análise , Prognóstico , Proteína Supressora de Tumor p53/análise , Neoplasias da Bexiga Urinária/química , beta Catenina/análise
4.
Actas urol. esp ; 30(9): 871-878, oct. 2006. ilus, tab
Artigo em Es | IBECS | ID: ibc-049447

RESUMO

Introducción: La historia natural del carcinoma superficial de vejiga (CSV) se caracteriza por su alta tasa de recidivas y por la capacidad de progresar a estadios infiltrantes. Vamos a investigar la capacidad de predicción de recidiva tumoral de la proteína p53, el antígeno Ki-67 y las moléculas de adhesión celular Cadherina E y Catenina Beta Material y método: 88 tumores T1 con una mediana de tiempo libre de enfermedad de 36 meses. Han recibido tratamiento profiláctico con BCG 81 mg. semanal durante seis semanas el 58% de la serie. Para p53 y Ki-67 se estableció el nivel de 10% de células teñidas para considerar positivo el tumor. Para Cadherina E y Catenina se han establecido dos grupos: uno con los valores 0-4 (negativo), y otro con los valores 5-8 (positivo). Resultados: Han recidivado el 31% de los tumores y progresado a estadio infiltrante el 3% La expresión de Ki-67 se correlaciona con grado (p ,002) y permeación linfática (p ,028). La multiplicidad tumoral con la falta de expresión de Cadherina E y Catenina Beta. Sólo la expresión de Ki-67 (p .049) y la de Catenina Beta (p .039) alcanzan significación estadística. En el estudio multivariante sólo la falta de expresión de Catenina Beta muestra tener valor pronóstico independiente para recidiva (p .049; O.R : 2,4-6,9) Conclusiones: Los marcadores más útiles son Ki-67 y Catenina Beta. Sólo la Catenina Beta muestra un valor independiente para recidiva tumoral. Los tumores que no expresan Catenina Beta o Cadherina E tienen un menor tiempo libre de recidiva


Introduction: The natural history of the superficial carcinoma of bladder is characterized by his high rate of recurrence and by the aptitude to progress to higher stages. We are going to investigate the capacity of prediction for tumor recurrence of protein p53, antigen Ki-67, E Cadherin and Beta Catenin Material and method: 88 T1 tumors with a median of free time of disease of 36 months. 58% of the serie has received prophylactic treatment with BCG 81 mg. weekly for six weeks. Cut-oof level for For P53 and Ki-67 is 10 % of stained cells. For E Cadherin and Beta Catenin we have established two groups: one with the values 0-4 (negative), and other one with the values 5-8 (positive). Results: Recurrence rate 31 %, stage progression 3 %. Ki-67 expression is correlated with grade (p .002) and lymphatic permeation (p .028). Multiplicity is correlated with lack( of Cadherin and Catenin´s expression. Only Ki-67 expression (p .049) and lack of Beta Catenin expression (p .039) reach statistical significance. In multivariant study only lack of Beta Catenin’s expression shows independent recurrence value (p .049; O.R: 2,4-6,9) Conclusions: The most useful prognmostic markers are Ki-67 and Catenina Beta Only Beta Catenin Beta shows independent value for tumour recurrence. Tumors wich lack expression for Catenin B or Cadherin E have lower recurrence free time


Assuntos
Humanos , Biomarcadores Tumorais/análise , Neoplasias da Bexiga Urinária/patologia , Estudos Prospectivos , Caderinas/análise , Antígeno Ki-67/análise , Proteína Supressora de Tumor p53/análise , Recidiva Local de Neoplasia/patologia
5.
Actas Urol Esp ; 29(1): 82-8, 2005 Jan.
Artigo em Espanhol | MEDLINE | ID: mdl-15786768

RESUMO

INTRODUCTION: Transitional bladder cancer is infrequent in younger people. The tumor's aggressiveness in this population is subject of discussion. We present our experience. MATERIAL & METHOD: 551 primary tumors, with at least one year of follow-up. Group A (less than 41 years old), Group B (bigger than 40 years old). We compare, stage, grade, lymphatic permeation, multiplicity, recurrence, progression, sex, T.L.E. (time free of disease), volume. We do uni and multivariate analysis. RESULTS: 17 tumors in younger than 41 years (2.1%). The recurrence rate is 11.8% in Group A and 36% in Group B (p .041). Progression rate: 0% in A and 4.1% in B (p .253). In Group A, T1 tumors (13.3% vs. 39%), G2 tumors (0% vs. 36.7%); withouts in lymphatic permeation (0% vs. 35%) and solitary tumors (13.3% vs. 35.3%) have statistically less recurrence. In univariate analysis we appreciate statistical differences in relation with grade (p .002) and sex (p .011). In multivariate analysis, stage, "group of age" and prophylactic treatment are independent variables for recurrence, and grade for progression. CONCLUSIONS: In younger than 41 years old: Less pathologic aggressivity (0% G3); Group of age is independent prognostic variable for recurrence, but not p for progression, despite a "less aggressive behaviour": 11.8% recurrence, 0% progression; T.L.E. bigger (one year more); Higher incidence in women (41% vs. 11%); Less recurrence in T1 tumors (13.3% vs. 39%), G2 tumors (0% vs. 36.7%) and solitary tumors (13.3% vs. 35.32%).


Assuntos
Carcinoma de Células de Transição/epidemiologia , Neoplasias da Bexiga Urinária/epidemiologia , Adulto , Distribuição por Idade , Fatores Etários , Idoso , Carcinoma de Células de Transição/patologia , Cistectomia , Progressão da Doença , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Análise Multivariada , Recidiva Local de Neoplasia , Estadiamento de Neoplasias , Recidiva , Análise de Sobrevida , Neoplasias da Bexiga Urinária/patologia
6.
Actas Urol Esp ; 27(8): 594-604, 2003 Sep.
Artigo em Espanhol | MEDLINE | ID: mdl-14587234

RESUMO

INTRODUCTION: In our experience we often observe urinary upper tract dilatation after urinari diversion with bowel. To spare useful approaches and therapeutics we have used diuretic renogram. MATERIAL AND METHOD: 26 patients with urinary diversion (Mainz II or Paduana ileal neobladder). We performance ultrasound, urography and diuretic renogram. RESULTS: Follow-up is between 1 y 4 years. After urinary diversion, 54% of the upper tracts are dilated but only 39.3% of them are obstructed in the diuretic renogram. Normal urographic tracts are normal or have good response in the diuretic renogram. Results goes on in the time. CONCLUSIONS: Diuretic renogram is a useful tool in the diagnosis of upper urinary tract obstruction after urinary diversion.


Assuntos
Diuréticos , Furosemida , Nefropatias/diagnóstico por imagem , Complicações Pós-Operatórias/diagnóstico por imagem , Renografia por Radioisótopo/métodos , Doenças Ureterais/diagnóstico por imagem , Derivação Urinária/métodos , Cistectomia , Dilatação Patológica/diagnóstico por imagem , Seguimentos , Humanos , Íleo/cirurgia , Nefropatias/etiologia , Nefropatias/patologia , Radiografia , Doenças Ureterais/etiologia , Doenças Ureterais/patologia , Obstrução Ureteral/diagnóstico por imagem , Obstrução Ureteral/etiologia
7.
Actas Urol Esp ; 27(9): 713-7, 2003 Oct.
Artigo em Espanhol | MEDLINE | ID: mdl-14626681

RESUMO

INTRODUCTION: There are many techniques describe for ureteroenteric anastomoses. We present our experience with three of them inorder to reduce the stenosis rate. METHOD AND MATERIAL: We have done radical cystectomy in 77 patients. Urinary diversion with small bowel in 20 patients (Paduana ileal neobladder) and dstubulized ureterosigmoidostomy (MainzII) in 55. Initially, we used Le Duc technique, afterward Ricard technique and actually bivalva technique (direct). RESULTS: We have performed Le Duc in 38%, Ricard in 31% and "bivalva" in 27%. Median follow-up are 37.7 months, 19.9 months and 10 months respectively. Stenosis: 16.7% with Le Duc; 20.5% with Ricard and 9.1% with bivalva technique. Renal anulation: 10.4% with Le Duc; 10.3% with Ricard and 0% with bivalva (p .000). CONCLUSIONS: In our experience, the less stenosant anastomose is BivalvaIn one. The simpliest technique, the best results. The rate of stenosis is higher when the upper urinary tract is dilatated pre-surgery, independently of the anastomosis technique.


Assuntos
Colo Sigmoide/cirurgia , Intestino Delgado/cirurgia , Ureter/cirurgia , Anastomose Cirúrgica/métodos , Cistectomia , Seguimentos , Humanos , Procedimentos Cirúrgicos Urológicos/métodos
8.
Actas urol. esp ; 27(9): 713-717, oct. 2003.
Artigo em Es | IBECS | ID: ibc-25214

RESUMO

INTRODUCCIÓN: Están descritas numerosas técnicas para el reimplante ureterointestinal. Presentamos nuestra evolución con tres de ellas con la intención de disminuir la incidencia de estenosis. MATERIAL Y MÉTODO: 77 pacientes a los que hemos realizado cistectomía radical y derivación urinaria con intestino delgado en 20 pacientes (neovejiga tipo Paduana) o con sigma destubulizado en 57 (Mainz II). Inicialmente realizábamos anastomosis según técnica de Le Duc, posteriormente puño de camisa (Ricard) y actualmente anastomosis tipo bivalva. RESULTADOS: Hemos realizado anastomosis tipo Le Duc en el 38 por ciento y puño de camisa en el 31 por ciento, bivalva en el 27 por ciento de las vías urinarias. Seguimiento medio 37,7 meses, 19,5 meses, y 10 meses respectivamente. Estenosis: 16,7 por ciento con técnica Le Duc; 20,5 por ciento con técnica Ricard; 9,1 por ciento con técnica Bivalva. Anulación renales: 10,4 por ciento con técnica Le Duc; 10,3 por ciento con técnica Ricard; 0 por ciento con técnica Bivalva (p .000).CONCLUSIONES: En nuestra experiencia la anastomosis menos estenosante es la tipo bivalva. A mayor sencillez de técnica mejores resultados. La tasa de estenosis es siempre mayor cuando la vía está dilatada previa a la derivación, independientemente de la técnica utilizada (AU)


Assuntos
Humanos , Colo Sigmoide , Procedimentos Cirúrgicos Urológicos , Ureter , Cistectomia , Anastomose Cirúrgica , Intestino Delgado , Seguimentos
9.
Actas urol. esp ; 27(8): 594-604, sept. 2003.
Artigo em Es | IBECS | ID: ibc-24746

RESUMO

INTRODUCCIÓN: En nuestra experiencia es frecuente la dilatación de la vía urinaria superior tras la derivación urinaria con intestino. Para ahorrar actitudes terapéuticas innecesarias y distinguir que vías están dilatadas funcionalmente y cuales secundarias a estenosis ureterointestinal hemos utilizado el renograma isotópico diurético. MATERIAL Y MÉTODO: 26 pacientes a los que se les ha realizado derivación intestinal bien tipo Mainz II bien tipo Paduana. Realizamos ecografía abdominal, urografía intravenosa, renograma diurético y urografía intravenosa. RESULTADOS: El seguimiento oscila entre 1 y 4 años. El 54 por ciento de las vías tras derivación están dilatadas, de las cuales sólo el 39,3 por ciento muestran patrón obstructivo en el renograma diurético, confirmándose la estenosis en el manejo endourológico de la misma. Las vías urográficamente normales son normales o responden a diurético en el renograma. El 75 por ciento de las vías anuladas funcionalmente en el urograma están anuladas en el renograma. Los resultados se mantienen a lo largo del seguimiento de estos enfermos. CONCLUSIONES: El renograma diurético es útil para distinguir que vía dilatada está obstruida de cual no lo está. Los resultados se mantienen en el tiempo (AU)


Assuntos
Humanos , Doenças Ureterais , Obstrução Ureteral , Derivação Urinária , Cistectomia , Complicações Pós-Operatórias , Renografia por Radioisótopo , Dilatação Patológica , Nefropatias , Seguimentos , Furosemida , Diuréticos , Íleo
10.
Actas Urol Esp ; 27(4): 260-4, 2003 Apr.
Artigo em Espanhol | MEDLINE | ID: mdl-12830546

RESUMO

INTRODUCTION: It is not usual to use as prognostic factor the bladder lymphatic vessels invasion. METHOD & MATERIAL: 519 T1 bladder tumors with complete resection and follow up of one year at least. Prophylaxis with 81 mg of BCG weekly during six weeks in 54%. RESULTS: Follow up without recurrence of 38 months. 49%. Tumour recurrence of 49% and progression of 7%. 5.8% of the tumours are L1 and 70.7% L0. There are significative statistic relation between lympatic invasion and progression (p. 005), tumoral grade (p. 000) and actual situation (p. 02). 23% of the L1 tumours progressed vs 5% of L0. Prophylaxis with BCG reduces progression risk (33% without treatment vs 16 with BCG (p n.s.)). In multivariate analysis, resected volume (p. 024) and prophylactic treatment are independent variables for recurrence and lymphatic vessels invasion (p. 0478) and tumoral grade (p. 092) for progression. CONCLUSIONS: 1) L1 tumours has more probabilities of progression. 2) BCG disminishes progression rate but this is not statistical significative. 3) We need new markers to select which L1 tumours will progress.


Assuntos
Metástase Linfática , Neoplasias da Bexiga Urinária/patologia , Administração Intravesical , Idoso , Vacina BCG/uso terapêutico , Terapia Combinada , Cistectomia , Progressão da Doença , Feminino , Seguimentos , Humanos , Imunoterapia , Masculino , Pessoa de Meia-Idade , Invasividade Neoplásica , Recidiva Local de Neoplasia , Estadiamento de Neoplasias , Neoplasias Primárias Múltiplas/patologia , Prognóstico , Risco , Neoplasias da Bexiga Urinária/cirurgia , Neoplasias da Bexiga Urinária/terapia
11.
Actas Urol Esp ; 25(1): 32-45, 2001 Jan.
Artigo em Espanhol | MEDLINE | ID: mdl-11284366

RESUMO

OBJECTIVE: Evaluate the utility of Ki-67 label index, p53 expression and flow cytometry-DNA ploidy in the selection of groups to be treated with prophylactic BCG and the prognostic value compared with the classic variables (grade, lymphatic permeation, multiplicity, volume, primary). MATERIAL & METHOD: 121 superficial bladder tumors T1. 10% Cut-off level for Ki-67 and p53. Aneuplody is defined as a tumor with DNA index different of 1 or more than 20% in G2-M phase. 71 (58.7%) received BCG. RESULTS: In uni and multivariate analysis positivity to Ki-67 is correlated with recurrence. Progression is correlated with lymphatic permeation (p .0003), volume (p .016), ploidy (p .022) and positivity to p53 (p .007). In multivariate analysis, volume and positivity to p53 are independent variables. None were of utility to prevent recurrence, but Ki-67 positive or aneuploid treated tumors had less progression (p .025 and p .009 respectively). The p53 negative treated tumors had less progression too. CONCLUSIONS: Only Ki-67 is correlated with tumoral recurrence. P53 and tumor volume are correlated with stage progression. If the results are confirmed with bigger series, the Ki-67 positive and/or aneuploid tumors would obtain benefits of prophylactic treatment with BCG.


Assuntos
Adjuvantes Imunológicos/uso terapêutico , Vacina BCG/uso terapêutico , Regulação Neoplásica da Expressão Gênica/genética , Antígeno Ki-67/genética , Ploidias , Proteína Supressora de Tumor p53/biossíntese , Neoplasias da Bexiga Urinária/genética , Neoplasias da Bexiga Urinária/prevenção & controle , Idoso , Feminino , Citometria de Fluxo , Humanos , Masculino , Estadiamento de Neoplasias , Prognóstico , Estudos Retrospectivos , Proteína Supressora de Tumor p53/genética , Neoplasias da Bexiga Urinária/patologia
12.
Arch Esp Urol ; 54(10): 1117-20, 2001 Dec.
Artigo em Espanhol | MEDLINE | ID: mdl-11852520

RESUMO

OBJECTIVE: Indinavir is a protease inhibitor used in the treatment of HIV with a lithogenic capacity as a urological side effect. The pathogenesis, diagnosis and treatment of indinavir urolithiasis are briefly reviewed. METHODS: A 37-year-old male, seropositive for HIV on treatment with indinavir, lamiduvine and zidovudine, consulted for colicky left lumbar pain, nausea, vomiting and dark urine for the past three days. RESULTS: Patient evaluation showed a nonfunctioning left kidney and ureterohydronephrosis of unknown origin. URS showed a yellowish, friable material with a mucinous appearance that occupied the entire lumen of the ureter. Fragmentation was achieved with the lithotriptor probe. Six months later the patient had fully recovered and was asymptomatic. CONCLUSIONS: The incidence of protease inhibitor-induced urolithiasis is increasing. This condition should be distinguished from uric acid calculi whose treatment will aggravate the indinavir urolithiasis.


Assuntos
Inibidores da Protease de HIV/efeitos adversos , Soropositividade para HIV/complicações , Indinavir/efeitos adversos , Cálculos Renais/induzido quimicamente , Adulto , Humanos , Masculino
13.
Arch Esp Urol ; 53(5): 468-9, 2000 Jun.
Artigo em Espanhol | MEDLINE | ID: mdl-10961013

RESUMO

OBJECTIVE: To describe an uncommon case of iatrogenic bladder lithiasis in a female patient who underwent colposuspension according to the Burch technique. METHODS/RESULTS: A female patient who had undergone colposuspension for urinary stress incontinence presented with irritative bladder symptoms and dyspareunia two years later. Patient evaluation revealed stone formation on the nonresorbable suture. Stone removal was achieved endoscopically using local anesthesia and without compromising continence. CONCLUSION: Removal of the calculus that had formed on the suture was achieved by endoscopy without compromising continence.


Assuntos
Complicações Pós-Operatórias/etiologia , Cálculos da Bexiga Urinária/etiologia , Incontinência Urinária por Estresse/cirurgia , Feminino , Humanos , Pessoa de Meia-Idade
14.
Actas Urol Esp ; 24(10): 785-95, 2000.
Artigo em Espanhol | MEDLINE | ID: mdl-11199294

RESUMO

OBJECTIVE: Observe the correlation between Ki-67 label index, p53 expression and flow cytometry-DNA ploidy with the classic variables (grade, lymphatic permeation, multiplicity, volume, primary). MATERIAL AND METHOD: 121 superficial bladder tumors T1. 10% Cut-off level for Ki-67 and p53. Aneuploidy is defined as a tumor with DNA index different of 1 or more than 20% in G2-M phase. RESULTS: Statistical correlation with grade and lymphatic permeation. Ki-67 label index and p53 expression can distinguish between G1, G2 vs G3 and Lx, L0 vs. L1. The volume correlates with positivity to p53. CONCLUSIONS: Aneuploidy and positivity to Ki-67 and p53 increase with grade and lymphatic permeation.


Assuntos
Regulação Neoplásica da Expressão Gênica , Antígeno Ki-67/análise , Ploidias , Proteína Supressora de Tumor p53/genética , Neoplasias da Bexiga Urinária/genética , Idoso , Feminino , Citometria de Fluxo , Humanos , Masculino , Estudos Retrospectivos
15.
Arch Esp Urol ; 52(7): 760-8, 1999 Sep.
Artigo em Espanhol | MEDLINE | ID: mdl-10540766

RESUMO

OBJECTIVE: To evaluate the utility of prophylactic treatment of stage T1 superficial tumors of the bladder with 27 mg BCG weekly for 6 weeks and to compare the results reported in the literature. METHODS: BCG instillations were offered to 235 patients and was accepted by 111 (group A) and refused by 124 (group B). Three weeks thereafter, intravesical instillation of 27 mg BCG was administered for 6 weeks. The patients were controlled regularly according to the standard control procedures utilized in our setting. RESULTS: 39% of the patients in group A showed recurrence versus 71.7% of those in group B (p < 0.001). No differences in progression of tumor stage was observed; 6.3% for group A and 10.9% for group B. By grade, significant differences were found in the number of recurrence in those with G1 (28.5% vs 69%; p < 0.001) and G2 (47% vs 72%; p < 0.01) tumors, but not for G3 (53% vs 77%; p = n.s.). No differences were found in the number of progressions. For those with G2 and G3, the results were not as good as those reported in the literature. The incidence of toxicity was 33%. CONCLUSIONS: The results achieved in patients with G2 and especially G3 tumors were not as good as those reported in the literature, therefore we do not recommend this approach. For those with G1 tumors and assuming a toxicity rate of 33%, the results are similar to those reported elsewhere using higher doses, and therefore this approach could be utilized.


Assuntos
Vacina BCG/administração & dosagem , Neoplasias da Bexiga Urinária/prevenção & controle , Vacina BCG/efeitos adversos , Terapia Combinada , Progressão da Doença , Relação Dose-Resposta a Droga , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Recidiva Local de Neoplasia/epidemiologia , Estadiamento de Neoplasias , Fatores de Tempo , Neoplasias da Bexiga Urinária/patologia
16.
Arch Esp Urol ; 52(5): 465-70, 1999 Jun.
Artigo em Espanhol | MEDLINE | ID: mdl-10427884

RESUMO

OBJECTIVE: To identify the prognostic factors for recurrence and disease progression in T1 superficial carcinoma of the bladder for prophylactic therapeutic planning. METHODS: Of 309 patients with superficial carcinoma of the bladder that had only undergone TUR, we selected 196 patients that met the following requirements: T1 tumor, one year minimum follow-up (except for recurrence), TUR complete on gross examination. The changes observed with recurrence (presence of a tumor regardless of grade or stage) and disease progression (higher tumor stage and therefore infiltrating) in the following parameters were analyzed: tumor grade, node involvement, volume resected, number of tumors, primary or recurrent and age. RESULTS: 141 (72%) showed recurrence and 23 disease progression (11.7%) at two-years' mean follow-up. The resected tumor volume was found to be a prognostic factor for recurrence by univariate (0.010) and multivariate analysis (0.039). Tumor grade (0.0005) and node involvement (0.040) were prognostic factors for disease progression by univariate analysis and tumor grade (0.006) by multivariate analysis. CONCLUSIONS: Resected tumor volume, node involvement and tumor grade were found to be prognostic factors. The incidence of disease progression in this series falls within the lower ranges reported in the literature.


Assuntos
Carcinoma/diagnóstico , Neoplasias da Bexiga Urinária/diagnóstico , Idoso , Carcinoma/patologia , Distribuição de Qui-Quadrado , Progressão da Doença , Feminino , Humanos , Modelos Logísticos , Masculino , Pessoa de Meia-Idade , Análise Multivariada , Recidiva Local de Neoplasia/diagnóstico , Recidiva Local de Neoplasia/patologia , Estadiamento de Neoplasias , Prognóstico , Neoplasias da Bexiga Urinária/patologia
17.
Actas Urol Esp ; 23(3): 256-62, 1999 Mar.
Artigo em Espanhol | MEDLINE | ID: mdl-10363382

RESUMO

An histo-ultrasound correlation was carried out between the information obtained with pre-operative transrectal ultrasound and that obtained with the histopathological study of 29 prostate specimens from patients with mean age 63 years (range, 52 to 71 years), who underwent radical cystoprostatectomy for infiltrant neoplasia of the bladder (22/29) and radical prostatectomy for prostate cancer (7/29). The (extrinsic and intrinsic) ultrasound parameters were analyzed focusing in the study of the prostatic capsule or "pseudocapsule". With this comparative, echographic and histological study the concept of capsular "pseudorupture" that results from the presence of (arterial and/or venous) vessels, nerves and fibromuscular folds at the periprostatic fat tissue is introduced. The interruption of the capsular echogram was seen as an indication of tumoral involvement of the capsule, and extracapsular spread. Our results allow us to suggest that this assertion should be reconsidered since these capsular "interruptions", "irregularities" or "pseudoruptures" are present in the normal prostate. Similarly, glandular asymmetry in relation with an heterogenous growth in one lobe in defined to differentiate it from that seen in neoplastic processes.


Assuntos
Próstata/diagnóstico por imagem , Próstata/patologia , Neoplasias da Próstata/diagnóstico por imagem , Neoplasias da Próstata/patologia , Idoso , Humanos , Masculino , Pessoa de Meia-Idade , Ultrassonografia
18.
Actas Urol Esp ; 23(10): 843-7, 1999.
Artigo em Espanhol | MEDLINE | ID: mdl-10670125

RESUMO

We present our experience in eighty patients with superficial bladder cancer stage T1. They have been randomized to receive BCG 27 mg weekly x 6 and monthly until complete one year (Group A) or the same schedule plus Tegafur 800 mg daily until complete one year. Results are similar in both groups. With a median follow up of two years and a half, 33% in Group A and 20% in Group B have had recurrence; 7.6% in group A and 3% in group B have had progression in stage. Differences are not significant in both cases. Tolerance of Tegafur is good with only 11% of secondary effects. We concluded that there are no differences in both treatments but there is a trend to better results with combinant therapy. It is necessary more patients to achieve definitive results.


Assuntos
Adjuvantes Imunológicos/administração & dosagem , Antimetabólitos Antineoplásicos/administração & dosagem , Vacina BCG/administração & dosagem , Tegafur/administração & dosagem , Neoplasias da Bexiga Urinária/tratamento farmacológico , Administração Oral , Idoso , Quimioterapia Combinada , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estadiamento de Neoplasias , Estudos Prospectivos , Fatores de Tempo , Neoplasias da Bexiga Urinária/patologia
19.
Actas Urol Esp ; 22(8): 655-60, 1998 Sep.
Artigo em Espanhol | MEDLINE | ID: mdl-9835084

RESUMO

We show our results in the diagnostic and follow-up of the bladder tumors comparing de BTA test with Void Cytology, in order to substitute this with the former. We performed BTA test, Void Cytology (of the same sample) and abdominal ultrasound to 133 patients. They are divided in three groups: 45 with bladder tumor, 16 healthy controls, 72 in follow-up with and without prophylaxis. The sensibility and specificity in tumor's group were similar. In controls' and follow-up's groups the void cytology specificity was superior. There is a high number of false positives in the follow-up group with a large number of "white" cystoscopes. A high number of false positives was seen if the BTA test was done in he first three months of follow-up. In the subgroup in prophylaxis with cystostatic there weren't false positives. We conclude that BTA test is useful in the diagnostic of bladder tumor but not in the follow-up, especially in the first three months.


Assuntos
Antígenos de Neoplasias/urina , Neoplasias da Bexiga Urinária/diagnóstico , Humanos , Sensibilidade e Especificidade , Neoplasias da Bexiga Urinária/imunologia , Neoplasias da Bexiga Urinária/terapia , Neoplasias da Bexiga Urinária/urina
20.
Arch Esp Urol ; 49(1): 55-8, 1996.
Artigo em Espanhol | MEDLINE | ID: mdl-8678600

RESUMO

OBJECTIVE: A case of upper calyx obstruction of the left kidney from an artery encroaching on the infundibulum is described. Treatment was by percutaneous insertion of a prosthesis. The results show the usefulness of the percutaneous approach in the treatment of this condition. METHODS: A Palmaz prosthesis was inserted into the obstructed infundibulum through a nephrostomy. Intravenous urography was performed immediately postoperatively and at 3, 6 and 12 months. RESULTS: No complications were observed postoperatively. At one-year follow-up the patient is asymptomatic and the urographic controls show improvement. CONCLUSIONS: Percutaneous insertion of a prosthesis in the treatment of infundibular stenosis had achieved good results in the case described herein, although a larger series and long-term follow-up are required to determine the usefulness of this approach.


Assuntos
Cálices Renais , Constrição Patológica/diagnóstico por imagem , Constrição Patológica/cirurgia , Feminino , Humanos , Cálices Renais/diagnóstico por imagem , Pessoa de Meia-Idade , Radiografia , Síndrome
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